Ti-8Ta-3Nb 합금의 표면처리에 의한 백서 두개관 세포의 반응
Biological response of primary rat calvarial cell by surface treatment of Ti-8Ta-8Nb alloy
김해진, 박지일, 정현주, 김영준, 손미경,
소속 상세정보
김해진 ( Kim Hae-Jin ) - 전남대학교 치의학전문대학원 치주과학교실
박지일 ( Park Ji-Il ) - 광주보건대학교 치위생과
정현주 ( Chung Hyun-Ju ) - 전남대학교 치의학전문대학원 치주과학교실
김영준 ( Kim Young-Joon ) - 전남대학교 치의학전문대학원 치주과학교실
손미경 ( Son Mee-Kyung ) - 조선대학교 치과대학 보철학교실
KMID : 0363020080380040595
Abstract
Purpose: Ti-6Al-4V alloy is widely used as an implant material because of its good biocompatibility and good mechanical property compared with commercial pure titanium. Otherwise, toxicity of aluminum and vanadium in vivo has been reported. Ti-8Ta-3Nb alloy is recently developed in the R&D Center for Ti and Special Alloys and it was reported that this alloy has high mechanical strength, no cytotoxicity and similar biocompatibility to commercial pure titanium, but many studies are needed for its clinical use. In these experiment, we carried out different surface treatment on each Ti-8Ta-3Nb alloy disks, then cultured cell on it and assessed biological response.
Materials and Methods: cpTi, Ti-6Al-4V, Ti-8Ta-3Nb alloy disks were prepared and carried out sandblasting and acid etching (SLA) or alkali-heat treatment (AH) on the Ti-8Ta-3Nb alloy disks. We cultured primary rat calvarial cells on each surface and assessed early cell attachment and proliferation by scanning electron microscopy, cell proliferation, alkaline phosphatase activity.
Result: The rates of cell proliferation on the cpTi, Ti-8Ta-3Nb AH disks were higher than others (p<0.05) and alkaline phosphatase activity was significantly enhanced on the Ti-STa-8Nb AH disks(p<0.05).
Conclusion: Most favorable cell response was shown on the Ti-8Ta-3Nb AH surfaces. It is supposed that alkali-heat treatment of the Ti-8Ta-3Nb alloy could be induced earlier bone healing and osseointegration than smooth surface.
키워드
Ti-8Ta-3Nb;alkali-heat treatment
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